Clinical Significance:

Total protein is useful for monitoring gross changes in protein levels caused by various disease states. It is usually performed in conjunction with other tests such as serum albumin, liver function tests or protein electrophoresis. An albumin/globulin ratio is often calculated to obtain additional information. Increased levels of serum protein are observed in dehydration, multiple myeloma and chronic liver disease. Decreased levels are encountered in renal diseases and terminal liver failure.

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